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The symptoms and signsare dependent on tumor location. This Mallory-stained specimen shows a spicule made of calci-fied cartilage (stained light blue) and a covering of bone tissue (staineddark blue).An osteoclast on the left side ofthe spicule has resorbed bonetissue and lies in adepression (Howship's lacuna) in the spicule.The lightband between the osteoclast and the bone spicule corresponds to theruffled border of the osteoclast.