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Germline alterations of components of thep53 signaling pathway such as BAX [ 7 ] BCL10 [ 67 ], CDKN2A [ 17 , 57 ], CHEK1[ 73 ], p63 [ 14 ], PTEN [ 16 , 17] and p73 [ 4] have not been documented. During the course of their lives following an UMN injury, adult andpediatric patients may benefit from multiple treatment options, includingnonpharmacologic treatment, oral medications, injectable agents (BoNT, phenol blocks),and/or surgery (17, 117, 118, 227, 228).
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